THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (LXRs) enhances degradation o

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A totally extraperitoneal approach for endoscopic resection of a congenital prepubic sinus through the pubic symphysis

Abstract Background A congenital prepubic sinus (CPS) is a rare congenital anomaly in which a duct remnant extends from the skin opening near the pubic symphysis to various parts and the lesions are mostly located in the preperitoneal space.The totally extraperitoneal (TEP) approach is an operational method that provides a good field of view for th

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The Effect of Using Dust of Crushed Boulders on Hma Properties

It is well recognized that mineral fillers play an important role in the properties of mastics and hot-mix asphalt (HMA) mixtures.Better understanding of the effects of fillers on the properties of mastics and HMA mixtures is crucial to good mix design and high performance of HMA mixtures.This paper presents a laboratory investigation into the effe

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Comparison and evaluation of neutralization of clinically frequently used antimicrobial agents using three different culture media in simulated blood cultures

ABSTRACT The performance of BACT/ALERT FA/FN Plus (France) blood culture containing a novel resin, DL (China) blood culture containing common resin, and adsorbent-free REDOX (USA) blood culture relying on dilution for antimicrobial neutralization at %peak serum concentration was evaluated by measuring the recovery of organisms and time to detection

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The effect of primary and preliminary methods of soil treatments and fertilizers on the productivity of field crop rotation link

The article Leisure al90d230k 90cm Electric Range Cooker Induction Top provides the results of 2014-2016 studies of the effect of macro- and micro fertilizers in the link of field crop rotation on fodder productivity and weed infestation on the background of basic and presowing cultivation of leached chernozem.The link of the crop rotation is prese

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